Why I like *computational* chemistry

Because, consider the alternative:

http://pipeline.corante.com/archives/2008/04/08/fun_with_tunichromes.php#comments

This is, I admit, about as bad as wet-lab chemistry gets; but it's pretty bad. Extracting a vanadium-binding protein, which decomposes in the presence of heat, light, oxygen, or most of the solid supports used in chromatography, from a couple of litres of the blood of sea-squirts, when each sea-squirt supplies very little blood, and your supply of sea-squirts, whilst large, is of indifferent freshness.

I strongly recommend pipeline.corante.com to chemistry groupies; the author is very good at conveying the frustration of medicinal chemistry.